Friday, September 27, 2002

Industry says that Roundup is a good pesticide, but may only be true relative to the really scary ones: this article links it to birth defects and endocrine dysfunction. however, the evidence cited for the first is epidemiological, i.e., weak:
Regarding the herbicide glyphosate, our present study shows a tentative association between ADD/ADHD and use of this herbicide. In vitro studies by our group show that this product was not genotoxic in the micronucleus assay (67) and did not have significant pseudoestrogenic effects in MCF-7 cells (37). In a recent review of the toxicology of glyphosphate (68), little if any evidence of neurotoxicity was noted other than by intentional ingestion (69).
The most interesting result of the in vitro study on mouse cells was this:
Although Roundup decreased steroidogenesis, the active ingredient of this herbicide, glyphosate, did not alter steroid production, indicating that at least one other component of the formulation is required to disrupt steroidogenesis. Because the formulation of Roundup is proprietary, further studies are needed to identify the components in Roundup and their ability to disrupt steroidogenesis.
According to PAN, 59% of Roundup is "inert".


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