Friday, March 05, 2004


M. Mahbubur Rahman, et al., "Induction and transmission of Bacillus thuringiensis tolerance in the flour moth Ephestia kuehniella," PNAS 101, no. 9 (March 2, 2004), 2696-2699. abstract:
The use of Bacillus thuringiensis (Bt) endotoxins to control insect vectors of human diseases and agricultural pests is threatened by the possible evolution of resistance in major pest species. In addition to high levels of resistance produced by receptor insensitivity, several cases of tolerance to low to medium levels of toxin have been reported in laboratory colonies of lepidopteran species. Because the molecular basis of some of these cases of tolerance to the toxin are not known, we explored alternative mechanisms. Here, we present evidence that tolerance to a Bt formulation in a laboratory colony of the flour moth Ephestia kuehniella can be induced by preexposure to a low concentration of the Bt formulation and that the tolerance correlates with an elevated immune response. The data also indicate that both immune induction and Bt tolerance can be transmitted to offspring by a maternal effect and that their magnitudes are determined by more than one gene.
Rainer Fischer, et al., "Plant-based production of biopharmaceuticals," Current Opinion in Plant Biology 7, Issue 2 , April 2004, 152-158. abstract:
Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The first plant-derived recombinant pharmaceutical proteins are reaching the final stages of clinical evaluation, and many more are in the development pipeline. Over the past two years, there have been some notable technological advances in this flourishing area of applied biotechnology, as shown by the continuing commercial development of novel plant-based expression platforms. There has also been significant success in tackling some of the limitations of plant bioreactors, such as low yields and inconsistent product quality, that have limited the approval of plant-derived pharmaceuticals.


Post a Comment

Links to this post:

Create a Link

<< Home

©2002-2005 by the author